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Watch this Webinar to Learn:

  • The key advantages of using 3D in vitro systems, such as 3D cell line cultures and patient-derived models including organoids
  • How model features, therapeutic, and target of interest can influence your decision to adopt a 3D in vitro platform for drug development
  • How to predict in vivo responses and select follow on models

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Watch This Webinar to Learn How to:

  • Enhance the translatability of in vitro studies by understanding cell line and organoid genomics
  • Assess novel combination regimens in vitro through effective study design and analysis
  • Uncover candidate biomarkers of response by harnessing in vitro data and genomics

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Download this QuickFact to Learn:

  • How to advance your combination therapy development programs using this new bioinformatics solution
  • How to evaluate and quantify two-drug combination effects (synergistic, antagonistic, and additive) for in vitro cell-based assays
  • To easily visualize and understand dose-response curve graphs, combination index graphs, inhibition heat maps for concentration combinations, 2-D contour maps, and 3D response surface plots

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Download this Quick Fact to learn:

  • How 3D patient-derived organoid models provide a highly translatable and reproducible in vitro platform
  • How to utilize organoids for immune cell co-culture assays based on the MoA of your agent
  • How to take advantage of the population diversity through our large, validated collection of organoids

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Download this Quick Fact to learn:

  • Understand the benefits of cell-based viability panel screens before moving into in vivo studies.
  • Choose from 2D and 3D platforms across multiple assay options.
  • Find out how to enroll now.

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Download This White Paper to Understand:

  • The key differentiators between in vitro systems, including conventional 2D platforms, 3D cultures including patient-derived models, and tumor organoids
  • How to select the right 3D in vitro platform for each stage of your drug development program based on model features, benefits, and limitations
  • How tumor organoids provide a superior and predictive research system for oncology drug development applications
  • The main applications of tumor organoids including high throughput screening, immunotherapy assessment, and enhanced in vivo model selection

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Download this Factsheet to Learn:

  • About this robust and reproducible ex vivo 3D assay platform that uses cells isolated from early passage PDX models
  • That there is over 70% correlation is shown in a retrospective analysis of in vivo data with our ex vivo results
  • How these panels can be used for standard of care drug screening, with varying efficacy observed for SoC agents tested across the colorectal PDX cell model panel

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Download This White Paper to Understand:

  • The importance of cell line selection, using collated databases containing large cell line collections, or bespoke model creation
  • How to select the correct downstream molecular biology assays to assess target expression, drug target inhibition, and tumor growth inhibition
  • How an integrated in vitro, ex vivo, and in vivo oncology portfolio allows go/no go decisions to be made with confidence, using a single, uniquely positioned provider

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Download the Report to:

  • Learn about key features, advantages, and limitations of 2D and 3D cell models in cancer drug development
  • Explore the advantages and current applications of tumor organoids in translating preclinical results
  • Understand how the use of tumor organoids is reshaping the future of oncology drug discovery

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CrownBio In Vitro Solutions

  • Learn more about our in vitro pharmacological services
  • 2D, 3D, Organoid Models are available and searchable via Crown databases
  • Learn more about specialized models that support Immuno-oncology specific studies

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