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Watch this Webinar to Learn:
- The key advantages of using 3D in vitro systems, such as 3D cell line cultures and patient-derived models including organoids
- How model features, therapeutic, and target of interest can influence your decision to adopt a 3D in vitro platform for drug development
- How to predict in vivo responses and select follow on models
Watch This Webinar to Learn How to:
- Enhance the translatability of in vitro studies by understanding cell line and organoid genomics
- Assess novel combination regimens in vitro through effective study design and analysis
- Uncover candidate biomarkers of response by harnessing in vitro data and genomics
Download this QuickFact to Learn:
- How to advance your combination therapy development programs using this new bioinformatics solution
- How to evaluate and quantify two-drug combination effects (synergistic, antagonistic, and additive) for in vitro cell-based assays
- To easily visualize and understand dose-response curve graphs, combination index graphs, inhibition heat maps for concentration combinations, 2-D contour maps, and 3D response surface plots
Download this Quick Fact to learn:
- How 3D patient-derived organoid models provide a highly translatable and reproducible in vitro platform
- How to utilize organoids for immune cell co-culture assays based on the MoA of your agent
- How to take advantage of the population diversity through our large, validated collection of organoids
Download this Quick Fact to learn:
- Understand the benefits of cell-based viability panel screens before moving into in vivo studies.
- Choose from 2D and 3D platforms across multiple assay options.
- Find out how to enroll now.
Download This White Paper to Understand:
- The key differentiators between in vitro systems, including conventional 2D platforms, 3D cultures including patient-derived models, and tumor organoids
- How to select the right 3D in vitro platform for each stage of your drug development program based on model features, benefits, and limitations
- How tumor organoids provide a superior and predictive research system for oncology drug development applications
- The main applications of tumor organoids including high throughput screening, immunotherapy assessment, and enhanced in vivo model selection
Download this Factsheet to Learn:
- About this robust and reproducible ex vivo 3D assay platform that uses cells isolated from early passage PDX models
- That there is over 70% correlation is shown in a retrospective analysis of in vivo data with our ex vivo results
- How these panels can be used for standard of care drug screening, with varying efficacy observed for SoC agents tested across the colorectal PDX cell model panel
Download This White Paper to Understand:
- The importance of cell line selection, using collated databases containing large cell line collections, or bespoke model creation
- How to select the correct downstream molecular biology assays to assess target expression, drug target inhibition, and tumor growth inhibition
- How an integrated in vitro, ex vivo, and in vivo oncology portfolio allows go/no go decisions to be made with confidence, using a single, uniquely positioned provider
Download the Report to:
- Learn about key features, advantages, and limitations of 2D and 3D cell models in cancer drug development
- Explore the advantages and current applications of tumor organoids in translating preclinical results
- Understand how the use of tumor organoids is reshaping the future of oncology drug discovery
CrownBio In Vitro Solutions
- Learn more about our in vitro pharmacological services
- 2D, 3D, Organoid Models are available and searchable via Crown databases
- Learn more about specialized models that support Immuno-oncology specific studies