That ESCC PDX models recapitulate patient disease preclinically, allowing the investigation of translational biomarkers of response
How a Mouse Clinical Trial across a cohort of PDX models identified a subset of responders to cetuximab monotherapy
That gene amplification and expression analysis indicated that high EGFR copy number, high EGFR mRNA expression, and IHC score of 2–3 associate with cetuximab response, indicating EGFR may function as a single predictive biomarker for cetuximab response in ESCC
Barcode deep NGS-based profiling, a more efficient and robust method for authenticating and detecting contamination in mouse and human samples compared to conventional STR and SNP analysis methods
How barcode deep NGS-based profiling enables large-scale authentication for the maintenance of high quality biobanks
How barcode deep NGS-based profiling can determine gender, ethnicity, detect viral infection, and mycoplasma contamination
How the genomic analysis of clinical samples has the potential to guide patient stratification, exemplified here for the Chinese ccRCC population
That 3 classes of ccRCC patient subgroups were identified, based on gene expression
Specific differences in gene mutations, e.g. PBRM1 mutation in the Chinese cohort investigated was much lower than for Caucasian cohort assessed by TCGA
How bioinformatics including biomarker discovery and validation, advanced study design and analysis, model selection, and evaluation of combination effects can add significant value to your drug candidate